Insulin Resistance (HOMA-IR)

The HOMA-IR is being used extensively for estimates of beta cell function and insulin resistance, both in clinical practice and studies, with the caveat that it cannot be used on patients on insulin.

HOMA-IR is a preferred estimate for insulin resistance as glucose clamp methods, the current gold standard, are resource intensive and time consuming.

Results from several studies have shown that there is reasonable correlation between the HOMA-IR and the glucose clamp measurement, however, agreement levels have shown that there is still room for refinement before the model can be fully implemented for clinical use.

Normal reference levels for HOMA-IR range between 0.7 and 2.0. Several studies use the 2.0 value as cut-off for increased insulin resistance.

About The Author:

Dr. Brian Mowll is a certified diabetes care and education specialist, master diabetes educator, and the medical director of SweetLife Diabetes Health Centers. He is the six-time host of the global Diabetes Summit, and of the #1 rated Mastering Blood Sugar podcast. He also serves of
the board of the Low Carb Diabetes Association.

Dr. Mowll has been helping patients and clients around the world to reverse type 2 diabetes and blood sugar problems through his personalized blood sugar programs for over 20 years. In addition, he speaks at health and diabetes conferences around the world and blogs at

Brian has four children and resides in Rehoboth Beach, Delaware.



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